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What Is Alprazolam

Alprazolam is a benzodiazepine derivative that was first introduced in the 1960s as an anxiolytic agent. It acts by binding with high affinity to GABA receptors throughout the brain. The drug has been used primarily for its anti-anxiety properties; however, it also possesses sedative effects when taken at higher doses. In addition to being available over the counter, alprazolam is marketed under several brand names including Xanax, Ativan, Valium, Tranquilize, Restoril, and others.

How does alprazolam work?

The mechanism of action of alprazolam involves allosteric modulation of gamma aminobutyric acid type A receptor complexes. This results in increased chloride ion conductance across neuronal membranes which leads to hyper-polarization of neurons and inhibition of neurotransmitter release from presynaptic terminals.

In clinical trials, alprazolam demonstrated efficacy comparable to lorazepam, diazepam, oxazepam, temazepam, flurazepam, midazolam, triazolam, zopiclone, and eszopliclomide.


Alprazolam is used to treat anxiety disorders panic disorders, and anxiety caused by depression.

Do NOT take this medicine if you are allergic to alprazolam, other benzodiazepines, or any of their components. If your doctor prescribes alprazolam for you, tell him/her about all medicines you use.Give ALPRaZolam only after consulting your physician if you have recently started using another prescription medication.